We offer Fmoc-protected unnatural amino acids for the synthesis of peptides for biological research and pharmaceutical development. By introducing conformational constraints, the peptides may have one or several of the following features: 1. enhancement of peptide backbone helicity for better target binding; 2. tunable hydrophobicity for desired cellular permeability and cytotoxicity; and 3. enhancement of peptide stability against proteolytic breakdown.
We offer nucleosides with modifications in both the nucleic acid base and the sugar component of the molecules. Nucleoside phosphoramidites are extremely useful chemical building blocks for the chemical synthesis of RNA-targeting drugs such as antisense oligonucleotides, aptamers, and siRNAs which have exhibited promises for treating diseases including muscular dystrophy, neuropathies, and macular degeneration.
dNTP, NTP, and modified nucleotides have exhibited a wide range of applications in PCR, RT-PCR, cRNA synthesis, RCA, MDA, DNA labeling, and sequencing. dNTPs are chemical building blocks in the commercial manufacture of mRNA vaccines using in vitro transcription method.
Inquire about our bulk quantities for the manufacture of oligonucleotide drug ingredients and large-scale production of mRNAs.
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Product Name: 2-Amino-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one Order number: 201164 CAS: 7355-55-7 Purity: >=95% Appearance: solid MF: C6H6N4O MW: 150.141 MP: n.a. oC Description: Deazapurine base for synthesizing nucleoside. |
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Product Name: (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-2-methylhept-6-enoic acid Order number: 201167 CAS: 288617-73-2 Purity: >=95% Appearance: solid MF: C23H25NO4 MW: 379.456 MP: n.a. oC Description: This alpha-methylated amino acid is used to make the peptide bond more stable against enzymatic hydrolysis. Helicity can be locked via Grubbs' methathesis reaction. |
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Product Name: 8-Azidoadenosine Order number: 201183 CAS: 4372-67-2 Purity: >=95% Appearance: solid MF: C10H12N8O4 MW: 308.258 MP: n.a. oC Description: This is a nucleoside for antiviral activity and potential labeling purpose via click chemistry. |
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Product Name: 2',3'-Dideoxyuridine Order number: 201284 CAS: 5983--09-5 Purity: >=95% Appearance: solid MF: C9H12N2O4 MW: 212.205 MP: n.a. oC Description: The dideoxyuridine nucleosides have found broad antiviral activities. |
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Product Name: 2'-Azido-2'-deoxyuridine Order number: 201288 CAS: 26929-65-7 Purity: >=95% Appearance: solid MF: C9H11N5O5 MW: 269.217 MP: n.a. oC Description: This is a nucleoside for antiviral activity and potential labeling purpose via click chemistry. |
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Product Name: 2-Thiothymidine Order number: 201294 CAS: 28585-51-5 Purity: >=95% Appearance: solid MF: C10H14N2O4S MW: 258.292 MP: n.a. oC Description: Thiothymidines have been used for anti-herpesvirus studies. |